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Based on the accumulated evidence of clinical trials and meta-analyses, combinations of clozapine with certain second-generation antipsychotic agents and the augmentation of antipsychotics with antidepressants seem recommendable, while the augmentation with mood stabilizers cannot be considered superior to placebo.

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Villeneuve E, Lemelin S (2005) Open-label study of atypical neuroleptic quetiapine for treatment of borderline personality disorder: impulsivity as main target.

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Roerig JL, Steffen KJ, Mitchell JE, Crosby RD, Gosnell BA (2008) A comparison of the effects of olanzapine and risperidone versus placebo on ghrelin plasma levels.

Clozapine appears to have more side effects than the other atypical antipsychotics.

In the absence of clinical or pharmacogenetic predictors of treatment response, the current treatment approach is largely one of trial and error across sequential medication choices.

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Correspondence: Dr HA Nasrallah, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670559, Cincinnati, OH, USA.

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HYPERPROLACTINEMIA IS A frequent and serious side-effect of conventional and second-generation antipsychotic drugs (SGA).

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Just as schizophrenia is not a single illness, cancer is a complex biological phenomenon made up of more than 100 anatomical subtypes, many of which are further divided into variants with differing histology, prognosis and response to treatment.

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Psychiatry suggest that symptoms of Asperger's disorder are improved by treatment with the atypical antipsychotic drug risperidone.

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Unanswered questions from this study include the respective roles of first-generation and second-generation antipsychotic medications and when clozapine should be used.

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The most widely used medications in the acute setting are lithium, some anticonvulsants (valproate, carbamazepine), standard antipsychotics (eg, haloperidol, chlorpromazine), atypical antipsychotics (eg, quetiapine, olanzapine, risperidone, ziprasidone, aripiprazole, clozapine), and benzodiazepines (eg, lorazepam, clonazepam).

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Incomplete remission of cognitive dysfunction remains the most important challenge of treatment research in schizophrenia.

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