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Based on the accumulated evidence of clinical trials and meta-analyses, combinations of clozapine with certain second-generation antipsychotic agents and the augmentation of antipsychotics with antidepressants seem recommendable, while the augmentation with mood stabilizers cannot be considered superior to placebo.

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Roerig JL, Steffen KJ, Mitchell JE, Crosby RD, Gosnell BA (2008) A comparison of the effects of olanzapine and risperidone versus placebo on ghrelin plasma levels.

Clozapine appears to have more side effects than the other atypical antipsychotics.

In the absence of clinical or pharmacogenetic predictors of treatment response, the current treatment approach is largely one of trial and error across sequential medication choices.

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Correspondence: Dr HA Nasrallah, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670559, Cincinnati, OH, USA.

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