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Foxo1a to facilitate 2-4 fold refractoriness to clinical agents capable of causing double-stranded DNA breaks and mitotic arrest (topotecan) more so than agent inducing single-strand breaks (mafosfamide, the active metabolite of cyclophosphamide).

Essential oil quality was unaffected and possessed antioxidant activity.

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If the chemical makes the skin sore, stop treatment until the discomfort has settled, then recommence as above.

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Leaves of another plant, Eastern red cedar, also contain podophyllotoxin but at substantially lower concentrations.

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Integration also faces other challenges stemming from key differences in how traditional and modern medicine is practised, evaluated and managed (see Table 2).

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