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If the PSA doubling time is less than six months, indicating that the cancer is aggressive, radiation therapy may not be adequate, as it is likely the cancer has already spread.

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Injectable leuprolide is injected once a day in a 1-mg dose to treat prostate cancer.

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ADT consists of treatment with a GnRH agonist, combined androgen blockade (GnRH analog plus antiandrogen), or, less commonly, bilateral orchiectomy.

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To counter this fact patients with a prostate larger than 50cc are offered neoadjuvant hormonal therapy to reduce their prostate volume to a value less than 50cc.

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Osteoporosis is common in prostate cancer patients receiving long-term continuous hormonal therapy, especially slender white men, men with positive family history of osteoporosis, and men taking steroids.

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The first LHRH antagonist, abarelix (Plenaxis), was approved by the US Food and Drug Administration (FDA) for advanced, symptomatic prostate cancer in late 2003.

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Furthermore, the finding in the overall EPC programme analysis of a trend towards a survival deficit in patients with localized disease who would otherwise have undergone watchful waiting was also seen within Trial 24 itself.

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Even men who have nerve-sparing prostatectomy can generally expect their posttreatment erections to be less robust than their preoperative ones.

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Gynecomastia, defined as benign proliferation of the glandular subareolar breast tissue, is an embarrassing and sometimes painful side effect experienced by men on ADT.

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